Clinical Trials

BRAIN TUMOR  
   

Please Visit: http://www.rtog.org/members/active.html#brain
        

   
EPILEPSY   
   
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Responsive Neurostimulator (RNS) System Pivotal-A Clinical Investigation
Paul Rutecki, MD
Karl Sillay, MD
NeuroPace, Inc. 
A research project testing a new treatment for seizures.  The treatment is the Responsive Neurostimulator (RNS) system which involves implanting a device in the head. When the RNS detects a seizure, it sends electrical signals to your brain.
MOVEMENT DISORDERS  
   

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Deep Brain Stimulation Device Battery Life Assessment: Medtronic Soletra and Kinetra
Karl Sillay, MD
Investigator Initiated 
This investigation is a 9-year retroactive chart review of all deep-brain stimulation cases performed at the University of Wisconsin Hospital and Clinics. We hope to uncover trends in stimulation parameters, impulse generator battery characteristics and electrode variations in order to provide insight into the intricacies of deep-brain stimulation technology. This research may provide clinicians with novel guidance and methodology for deep-brain stimulation therapy.
   

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Effects of Deep Brain Stimulation on Decision-Making for Eye Movements in Patients with Parkinson’s Disease
Karl Sillay, MD
Investigator Initiated 
Parkinson’s disease is traditionally considered a disorder of movement; however, certain patients also often experience cognitive symptoms. It has been suggested that DBS may alter performance on cognitive testing. This work seeks to extend recent investigations in humans and non-human primates, to humans with Parkinson’s disease being treated with deep-brain stimulation.
   
PEDIATRICS  
   
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Chiari Surgery Outcomes Study
Bermans Iskandar, MD
American Syringomyelia and Chiari Alliance Project Inc.
A research project collecting pilot data to evaluate surgical approaches and outcomes in surgery for patients with Chiari type I malformation and syringomyelia.  The study will collect data on the characteristics of subjects who ultimately undergo surgical intervention.  Dr. Iskandar and the University of Wisconsin School of Medicine and Public Health will be the coordinating center collecting and compiling data from 12 clinical sites across the United States.  
 
SPINE
   
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STROKE  
   
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Structural Stability of Carotid Plaque and Symptomatology
Robert Dempsey, MD 
National Institutes of Health 
A research project looking at the differences in the plaque in people with symptomatic and asymptomatic carotid stenosis (narrowing of the carotid arteries).  The study uses various techniques to look at the differences in people who have carotid stenosis and the causes and consequences of carotid stroke.
   
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Researching AXIUM™ Coiling Experience and Recanalization (RACER) Study
David Niemann, MD
ev3 Neurovascular
The ev3 Researching AXIUM™ Coiling Experience and Recanalization (RACER) Study is a single arm, prospective, non-randomized, US multi-center study surveying the continuing safety and effectiveness of AXIUM Coils for the treatment of intracranial saccular aneurysms that have a maximum diameter of 2mm to 20mm and are not amenable to treatment with surgical clipping.
 

 

Other  
   
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A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Progesterone in Patients with Severe Traumatic Brain Injury (SyNAPSe)
Joshua Medow, MD 
BHR Pharma, LLC
The goal of the SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recovery.
 

 

Additional Information:
Contact the Office of Clinical Trials at:
  608.265.6507  
  ctrials@clinicaltrials.wisc.edu  
Visit www.clinicaltrials.gov


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