 |
Home | Research | Daniel K. Resnick Research Laboratory |
|
| Research Interests |
|
Spinal Cord Injury: This research has focused on the development of novel treatments for spinal cord injury. We have worked to find methods to promote functional recovery as well as to alleviate neuropathic pain. We have studied the role of cyclooxygenase 2 inhibitors on functional recovery following acute spinal cord injury, the effect of stem cell and olfactory nerve ensheathing cell transplantation on recovery of function following spinal cord injury, and the influence of folic acid metabolism on functional recovery following spinal cord injury. Our recent studies have included genetic analysis of both the acute and chronically injured spinal cord using Genechip as well as RTPCR technologies. We recently completed an analysis of genetic changes observed in the dorsal column of the spinal cord of rats subjected to a loose ligation of the sciatic nerve, and found interesting alterations in the expression of several genes known to play a role in nociception. These alterations resolved as the behavioral evidence of allodynia resolved. We are currently in the final stages of describing an animal model for the assessment of pain behavior following spinal cord injury and intend to use this model to perform an in depth analysis of the factors responsible for the development of neuropathic pain following spinal cord injury. We also have a number of collaborative projects underway with members of the University of Wisconsin SCIRP (Spinal Cord Injury, Regeneration, and Plasticity) group. This group includes researchers from the department of neurological surgery as well as researchers from other departments, the veterinary medicine school, and other medical school departments. These experiments are designed to assess the mechanisms of plasticity of respiratory control following spinal cord injury, to assess the role of minocycline in the treatment of spinal cord injury, and to further our understanding of the role of individual gene products in influencing functional recovery. Biomechanics: We have recently received a grant from the Congress of Neurological Surgeons to study the biomechanical properties of a number of novel craniocervical junction fixation techniques. This study has been performed in close collaboration with Drs. Anderson and Zdeblick from the department of orthopedic surgery. We are in the final stages of data analysis and preparation of a manuscript. We anticipate further collaboration on a series of biomechanical studies funded through private and industry sources over the next several years. Other: We are involved in a series of studies designed to measure spinal cord blood flow using non-invasive techniques. These studies are being funded by the Amarican Syringomyelia Foundation and will hopefully lead to an improvement in our ability to diagnose and treat disorders of the spinal cord and craniocervical junction. Clinical Research Interests: Clinical Research Projects: I am primarily interested in the diagnosis and management of complex disorders of the spine. A particular interest of mine relates to the craniocervical junction. In addition to the biomechanical studies described above, recent clinical studies have included a prospective comparison of pedicle screw placement techniques, a blinded evaluation of radiographic techniques for the assessment of atlantoaxial dislocation, and an anatomical study of the feasibility of different craniocervical screw fixation techniques. In addition we recently completed a randomized controlled clinical trial assessing the effect of iliac crest reconstruction on post operative pain in patients undergoing cervical fusion. |
| Personnel |
|
Spinal Cord Injury Laboratory: • Daniel K. Resnick, MD MS • Gurwattan Miranpuri, PhD |
| Current Funding |
| • University of Wisconsin startup funds |
| Recent Publications |
| • | RESNICK DK, Graham SH, Dixon CE, Marion DW: The role of cyclooxygenase - 2 in acute spinal cord injury. Journal of Neurotrauma 15: 1005-1012, 1998. |
| • | RESNICK DK, Resnick NM, Welch WC, Cooper DJ: CD44 variant expression in tumors effecting the central nervous system. Molecular Diagnosis 4: 219-232, 1999. |
| • | Song G, Cechvala C, RESNICK DK, Dempsey RJ, Rao VLR: Gene expression analysis after acute spinal cord injury in rat. Journal of Neurochemistry 79: 1-13, 2001 |
| • | RESNICK DK, Nguyen P, Cechvala C. Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations following spinal cord injury. The Spine Journal 1: 432-436, 2001. |
| • | RESNICK DK, Nguyen P, Cechvala C. Selective cyclooxygenase 2 inhibition lowers spinal cord prostaglandin concentrations following traumatic injury. The Spine Journal 1: 437-441, 2001. |
| • | RESNICK DK, Catherine F. Cechvala, Yiping Yang, Brian C. Witwer, Dandan Sun, Suchun Zhang: Adult and Embryonic Olfactory Cell Transplantation for Acute Spinal Cord Injury. Journal of Neurotrauma 20: 279-285, 2003. |
| • | Badie B, Schartner J, Prabakaran S, Peebles TR, Bartley B, Lapsiwala S, Resnick DK, Vorpahl J: Microglia cyclooxygenase 2 expression: possible role in tumor edema formation. Clinical Cancer Research 9: 872-877, 2003. |
| • | RESNICK DK, Schmitt CE, Miranpuri GS, Dhodda VK, Isaacson J, Vemuganti RL: Molecular evidence of plasticity and repair in the chronically injured spinal cord. NeuroReport 15(5): 837-839, 2004. |
| • | RESNICK DK, Meletic G, Miranpuri GS, Vemuganti RL, Meletic V: Chronic spinal cord injury and neuropathic pain: mechanisms of plasticity. Submitted to Pain, 2004. |
|
|
|
| • | RESNICK DK, Lapsiwala S, Trost GR: Anatomic suitability of the C1-2 complex for pedicle screw fixation. Spine 24(14): 1494-1498, 2002. |
| • | Haughton VM, Rogers BP, Meyerand ME, RESNICK DK: Axial rotations measured in vivo by MRI in patients with back pain and unstable motion segments. American Journal of Neuro-Radiology 23: 1110-1116, 2002. |
| • | RESNICK DK: Prospective comparison of virtual fluoroscopy to fluoroscopy and plain radiographs for placement of lumbar pedicle screws. Journal of Spinal Disorders 16 (3): 254-260, 2003 |
| • | RESNICK DK: Prospective randomized trial of iliac crest reconstruction following graft harvest for cervical fusion. Submitted to Journal of Neurosurgery Spine, 2004. |
|
Home | Research | Daniel K. Resnick Research Laboratory |
| Send Email to editor of this page | Last update: September 9, 2001 |